At Concerto Biosciences, we are obsessed with microbes. We dream of a healthier world where microbial ecology enables advanced medicines and environmentally-conscious agricultural practices. To unlock microbial ecology, Concerto uses a novel screening technology from MIT to construct and observe millions of microbial cocultures in parallel—each its own tiny universe of possibilities. Our technology generates a totally new type of microbiome data that allows us to identify groups of microbes that perform beneficial functions. We call these groups “ensembles”. We are currently in the preclinical stage for our first product, an ensemble to treat eczema—a chronic, irritating, and psychologically stressful skin disease that affects over two hundred million people. Our goal is to discover the first-ever treatment that provides totally safe, sustained relief for eczema patients. Concerto will go on to develop a multitude of ensembles that solve the world’s greatest challenges in human health, food production, and bioremediation.
The Concerto team is our most important ensemble. We believe the best human ensembles, much like microbial ensembles, are diverse—composed of individuals with different backgrounds, cultures, genders, and beliefs. We are committed to building a company where you belong and where your voice is heard.
As the leader and manager of our fermentation team, your primary goal will be to develop Concerto’s first live biotherapeutic product (LBP), “Ensemble No.2” (ENS-002), into a Phase I-ready drug product. To this end, you will help set up a new, scale-appropriate, and phase-appropriate GMP manufacturing laboratory. You will lead the development of a bioprocess for the manufacturing of the ENS-002 drug substance, coordinate with Quality to develop and validate release assays, draft and review SOPs, MBRs, provide technical oversight for product disposition, manage distribution and clinical labeling of drug product lots, and manage relationships with CROs, CDMOs and regulatory consultants.
This role will require experience in traditional GMP manufacturing of biologics as well as willingness to experiment with and innovate on CMC pipelines for LBP manufacturing. We don’t expect you to have experience performing all of the responsibilities listed below. Indeed, just as you help Concerto grow, we hope to contribute to your intellectual and professional growth. You’ll have the opportunity to gain new skills by working with our world-class team, and you’ll also have the opportunity to advance within the company by taking on higher responsibility roles.
As an early member of Concerto’s expanding team, you’ll also play a critical role in developing Concerto’s culture and translating our core values into practice.