Direct discovery of microbial ensembles with advanced microbial interaction screening technology.
Unchecked virulence of a skin-dwelling microbe, Staphylococcus aureus, elicits and exacerbates eczema flares. On healthy skin, S. aureus is placated by interactions with virulence-inhibiting microbes making up the skin microbiome.
Concerto’s first product, ENS-002 (“Ensemble No.2”), is a group of microbes that restores protective microbial interactions, rehabilitating the skin microbiome and reducing S. aureus virulence >98%.
Phytophthora infestans, which resides in plant debris and soil, can invade potato and tomato tissue, causing a devastating disease called late blight that ends the crop season prematurely. Chemical fungicides, the existing solution, often do not work. What’s more: they cause environmental pollution and even human disease.
Like naturally occurring "suppressive soils", an ensemble for biocontrol would produce compounds that inhibit P. infestans from infecting plant tissue—a natural, sustainable, environmentally friendly way to protect crops.
In the axillary (armpit) microbiome, Staphylococcus and Corynebacterium decompose odorless sweat into the compounds responsible for body odor. Masking body odor with typical deodorants can exacerbate odor-producing conditions and cause allergic reactions.
An ensemble for body odor would resist the colonization and metabolic activity of odor-causing bacteria in order to eliminate body odor naturally and safely.
Associate Professor of Biological Engineering, MIT
Founder and leader of the Chicago Integrative Eczema Center
Affiliate Faculty at Northwestern University
Associate Professor of Dermatology at UCSF
Former SVP Business Development at Seres Therapeutics
Chief Business Officer at Surface Oncology
Managing Director of MassVentures
Former Director of the Technology Transfer Office at Boston University
Founder, Resilience Therapeutics
Head of Strategic Projects & Alliances, Delix Therapeutics
14 years of product experience in diagnostics, former Perkin Elmer and Roche